Oral Hypoglycemic Agents  in Pregnancy

Oral Hypoglycemic

Agents

 in Pregnancy

H. Delshad  MD

Endocrinologist

Research Institute for Endocrine Sciences

Gestational Diabetes Mellitus

• Congenital anomalies :

      □ Non-diabetic women : 2% to 3%

      □ Uncontrolled  DM in pregnancy : 7% to 9% 

• HAPO : Hyperglycemia below diagnostic levels for diabetes is similarly associated with adverse pregnancy outcomes
• Excellent blood glucose control results in improved perinatal outcomes

Gestational Diabetes Mellitus

• Lifestyle , diet and, when indicated, insulin, clearly improve outcomes in GDM
• Historically, insulin has been the therapeutic agent of choice
• Whilst effective, insulin has several disadvantages:

         ►The need for injection

         ►The risk of hypoglycemia

         ►Excessive weight gain

         ►Costs